Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9060539 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL8987336 | 0.87 | — | — | |
| SCHEMBL17149999 | 0.66 | — | — | |
| SCHEMBL762220 | 0.65 | — | — | |
| SCHEMBL4052233 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL6033043 | 0.63 | — | — | |
| Tribromoacetic Acid SCHEMBL11512302 | 0.63 | NOS3 (0.61) | — | |
| Hydrochlorthiazide SCHEMBL9106848 | 0.63 | NOS3 (0.61) | — | |
| Trichloroacetic Acid SCHEMBL11153895 | 0.63 | NOS3 (0.61) | — | |
| SCHEMBL8142930 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8239369-A | — | — | None | — | — | JP | disclosed |
| US-20250049736-A1 | SULFONAMIDE DERIVATIVES AND THEIR USE AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | THE US SECRETARY DEPARTMENT OF HEALTH (US) | 2025-02-13 | — | — | US | disclosed |
| EP-4448491-A2 | N-((ADAMANTAN-1-YL)CARBAMOYL)-BENZENESULFONAMIDE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF HYPERTENSION | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114366-A2 | SULFONAMIDE DERIVATIVES AND THEIR USE AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-06-22 | — | — | WO | disclosed |
| US-20140349969-A1 | COMPOUNDS AND METHODS FOR TREATING PAIN | AKRON MOLECULES AG (AT) | 2014-11-27 | — | — | US | disclosed |
| EP-2674161-A1 | FMO3 inhibitors for treating pain | Akron Molecules GmbH (AT) | 2013-12-18 | — | — | EP | disclosed |
| US-20130252924-A1 | Compounds and Methods for Treating Pain | AKRON MOLECULES GMBH (AT) | 2013-09-26 | — | — | US | disclosed |
| JP-H08239369-A | 2-AMINO-1,3-THIAZINE AS INHIBITOR AGAINST NITROGEN CARBON MONOXIDE SYNTHASE | HOECHST AG | 1996-09-17 | — | — | JP | disclosed |
| EP-0713704-A1 | 2-Amino-1,3-thiazines as nitric oxide synthase inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1996014842-A1 | SUBSTITUTED HETEROCYCLES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-05-23 | — | — | WO | disclosed |