SCHEMBL8983365

SCHEMBL8983365

CC(CCC(O)(P(=O)(O)O)P(=O)(O)O)NC(=O)CCCc1ccc(N(CCCl)CCCl)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.49
LMNA P02545 2/20 0.49
GMNN O75496 1/20 0.49
ALDH1A1 P00352 1/20 0.49
CYP2D6 P10635 1/20 0.49
MAPT P10636 1/20 0.49
GABRA1 P14867 1/20 0.49
TSHR P16473 1/20 0.49
NFKB1 P19838 1/20 0.49
THPO P40225 1/20 0.49
GABRA2 P47869 1/20 0.49
GABRB2 P47870 1/20 0.49
PMP22 Q01453 1/20 0.49
HIF1A Q16665 1/20 0.49
SLCO1B3 Q9NPD5 1/20 0.49
HDAC2 Q92769 2/20 0.47
HDAC3 O15379 1/20 0.47
NCOR1 O75376 1/20 0.47
HDAC8 Q9BY41 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9012797 0.84 HDAC6 (0.50) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL9012851 0.83 HDAC6 (0.49) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL9308693 0.83 HDAC6 (0.60) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL9012793 0.82 HDAC6 (0.48) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL9297863 0.82 HDAC6 (0.59) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL9012811 0.81 HDAC6 (0.46) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL8983387 0.80 KMT2A (0.51) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL9013070 0.80 CA12 (0.49) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL8983258 0.80 CA12 (0.59) HDAC6SMN1; SMN2LMNAGMNNALDH1A1
SCHEMBL8983307 0.80 CA12 (0.57) HDAC6SMN1; SMN2LMNAGMNNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593437-B1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA (IT) 1996-05-08 EP disclosed
EP-0593437-A1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. BOEHRINGER MANNHEIM ITALIA (IT) 1994-04-27 EP disclosed
US-5300671-A Gem-diphosphonic acids, and pharmaceutical compositions containing them BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1994-04-05 US disclosed
WO-1991005791-A1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1991-05-02 WO disclosed