SCHEMBL8983387

SCHEMBL8983387

CC(CCC(O)(P(=O)(O)O)P(=O)(O)O)NC(=O)[C@@H](N)Cc1ccc(N(CCCl)CCCl)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.51
CYP3A4 P08684 3/20 0.51
ALDH1A1 P00352 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
HIF1A Q16665 3/20 0.51
LMNA P02545 3/20 0.51
MEN1 O00255 3/20 0.51
ALOX15 P16050 2/20 0.51
NFKB1 P19838 2/20 0.51
THPO P40225 2/20 0.51
MAPT P10636 2/20 0.51
PMP22 Q01453 2/20 0.51
ABCB11 O95342 1/20 0.51
CHRM2 P08172 1/20 0.51
ADRA2A P08913 1/20 0.51
CHRM1 P11229 1/20 0.51
ACHE P22303 1/20 0.51
PTGS1 P23219 1/20 0.51
OPRM1 P35372 1/20 0.51
DRD3 P35462 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9122240 0.96 OPRM1 (0.47) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL9012828 0.84 OPRM1 (0.47) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL8983316 0.84 CYP3A4 (0.55) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL9012770 0.83 OPRM1 (0.46) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
Hydrochloric Acid SCHEMBL9014161 0.83 OPRM1 (0.46) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL9012813 0.83 CYP3A4 (0.45) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL9014312 0.83 OPRM1 (0.45) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL9013135 0.83 CYP3A4 (0.45) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
SCHEMBL8983269 0.82 CYP3A4 (0.53) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A
Hydrochloric Acid SCHEMBL8983345 0.81 CYP3A4 (0.52) KMT2ACYP3A4ALDH1A1SMN1; SMN2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593437-B1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA (IT) 1996-05-08 EP disclosed
US-5300671-A Gem-diphosphonic acids, and pharmaceutical compositions containing them BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1994-04-05 US disclosed
WO-1991005791-A1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1991-05-02 WO disclosed