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SCHEMBL8984643

SCHEMBL8984643

Cc1ccc(-c2c(-c3ccccc3Cl)cnc3c(C(=O)N[C@@H]4CCS(=O)(=O)C4)cnn23)cc1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ GLA P06280 1/20 0.46
▸ DGAT2 Q96PD7 13/20 0.43
▸ KDM4E B2RXH2 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ ATM Q13315 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4114345 0.93 DGAT2 (0.47) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4130217 0.93 DGAT2 (0.47) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL2085794 0.93 DGAT2 (0.47) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4120278 0.90 DGAT2 (0.43) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4125039 0.90 DGAT2 (0.42) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4106949 0.90 DGAT2 (0.42) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4120284 0.90 DGAT2 (0.43) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4120411 0.90 DGAT2 (0.43) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4106953 0.90 DGAT2 (0.42) SMN1; SMN2GLADGAT2KDM4ELMNA
SCHEMBL4115077 0.86 CNR1 (0.43) SMN1; SMN2DGAT2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188097-B2 Pyrazolo[1,5-A]pyrimidine compounds MITSUBISHI TANABE PHARMA CORPORATION (JP) 2012-05-29 — — US disclosed