Tryptophan

Tryptophan

SCHEMBL8984733

CSCC[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.Nc1ncnc2nc[nH]c12

nearest known ligand 0.54

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.54
MAPT P10636 4/20 0.54
MEN1 O00255 3/20 0.54
LMNA P02545 3/20 0.54
KDM4E B2RXH2 3/20 0.54
TSHR P16473 2/20 0.54
BLM P54132 2/20 0.54
PMP22 Q01453 2/20 0.54
MPO P05164 1/20 0.54
HIF1A Q16665 1/20 0.54
CTSC P53634 3/20 0.50
L3MBTL1 Q9Y468 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MAPK1 P28482 1/20 0.43
HTT P42858 1/20 0.43
GFER P55789 1/20 0.43
APAF1 O14727 1/20 0.42
POLB P06746 1/20 0.42
RECQL P46063 1/20 0.42
HSP90AA1 P07900 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Tryptophan SCHEMBL28132453 0.90 MAPT (0.64) KMT2AMAPTMEN1LMNAKDM4E
Dl-Tryptophan SCHEMBL8984731 0.87 KMT2A (0.55) KMT2AMAPTMEN1LMNAKDM4E
Tryptophan SCHEMBL16670999 0.84 MAPT (0.56) KMT2AMAPTMEN1LMNAKDM4E
Dl-Tryptophan SCHEMBL2229687 0.84 KMT2A (0.76) KMT2AMAPTMEN1LMNAKDM4E
Adenine SCHEMBL9663406 0.84 PI4KA (0.52) LMNAKDM4ETSHRHIF1ASMN1; SMN2
Dl-Tryptophan SCHEMBL23924440 0.84 KMT2A (0.76) KMT2AMAPTMEN1LMNAKDM4E
Dl-Tryptophan SCHEMBL11461241 0.84 KMT2A (0.76) KMT2AMAPTMEN1LMNAKDM4E
Tryptophan SCHEMBL2229691 0.84 KMT2A (0.76) KMT2AMAPTMEN1LMNAKDM4E
Adenine SCHEMBL23928077 0.83 PI4KA (0.54) LMNAKDM4ETSHRHIF1ASMN1; SMN2
Dl-Tryptophan SCHEMBL25193338 0.82 KMT2A (0.53) KMT2AMAPTMEN1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5580787-A NONTOXIC FOOD STARTER CULTURE Wessels, Stephen (DK) 1996-12-03 US disclosed