Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.65 |
| ▸ | NAT1 | P18440 | 5/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.63 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | MAX | P61244 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986259 | 1.00 | PIM1 (0.65) | PIM1NAT1CA2EPHX1MYC | |
| SCHEMBL18103073 | 1.00 | PIM1 (0.65) | PIM1NAT1CA2EPHX1MYC | |
| SCHEMBL18103082 | 0.89 | NAT1 (0.67) | PIM1NAT1CA2EPHX1MYC | |
| SCHEMBL18103099 | 0.86 | NAT1 (0.63) | PIM1NAT1CA2EPHX1MYC | |
| SCHEMBL8308593 | 0.86 | NAT1 (0.65) | PIM1NAT1CA2MYCMAX | |
| SCHEMBL8708716 | 0.86 | NAT1 (0.65) | PIM1NAT1CA2MYCMAX | |
| SCHEMBL1249977 | 0.85 | TTR (0.63) | PIM1NAT1GSK3B | |
| SCHEMBL1249979 | 0.85 | TTR (0.63) | PIM1NAT1GSK3B | |
| SCHEMBL12891881 | 0.85 | TTR (0.63) | PIM1NAT1GSK3B | |
| SCHEMBL18103072 | 0.83 | NAT1 (0.79) | PIM1NAT1CA2EPHX1MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579770-B1 | MACROCYCLIC LACTAM PROKINETIC AGENTS | ABBOTT LAB (US) | 1996-06-26 | — | — | EP | claimed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |