Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 4/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | CLK1 | P49759 | 1/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 3/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708716 | 1.00 | NAT1 (0.65) | NAT1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8986249 | 0.86 | PIM1 (0.65) | NAT1CA2PDE4BPIM1GSK3B | |
| SCHEMBL8986259 | 0.86 | PIM1 (0.65) | NAT1CA2PDE4BPIM1GSK3B | |
| SCHEMBL18103073 | 0.86 | PIM1 (0.65) | NAT1CA2PDE4BPIM1GSK3B | |
| SCHEMBL18103082 | 0.84 | NAT1 (0.67) | NAT1CA2PIM1KDM4EMEN1 | |
| SCHEMBL18103022 | 0.83 | NAT1 (0.77) | NAT1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL30250160 | 0.81 | CSNK2A2 (0.92) | NAT1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8309671 | 0.79 | NAT1 (1.00) | NAT1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8309670 | 0.79 | NAT1 (1.00) | NAT1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8312402 | 0.79 | CSNK2A2 (1.00) | NAT1CSNK2A2CLK1CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |