Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CTSV | O60911 | 1/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12871194 | 0.86 | HPGD (0.69) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL29612166 | 0.85 | HPGD (1.00) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL1173520 | 0.85 | HPGD (1.00) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL28133652 | 0.85 | HPGD (1.00) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL8987096 | 0.83 | HPGD (0.70) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL8987418 | 0.83 | HPGD (0.74) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL8987046 | 0.83 | HPGD (0.74) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL8987263 | 0.82 | HPGD (0.68) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL8986966 | 0.82 | KDM4E (0.71) | HPGDSMN1; SMN2MAPK1HTTTNKS2 | |
| SCHEMBL31677372 | 0.82 | KDM4E (0.71) | HPGDSMN1; SMN2MAPK1HTTTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106432074-B | A method of 4- aryl -2- quinolinone is prepared by carbon dioxide | 常州大学 | 2019-01-29 | — | — | CN | disclosed |
| CN-106432074-A | Method for preparing 4-aryl-2-quinolinone through carbon dioxide | 常州大学 | 2017-02-22 | — | — | CN | disclosed |
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |
| US-4758566-A | 2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, processes for the preparation thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1988-07-19 | — | — | US | disclosed |
| EP-0204003-A1 | 2-(1-PIPERAZINYL)-4-SUBSTITUTED PHENYLQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1986-12-10 | — | — | EP | disclosed |