SCHEMBL8987408

SCHEMBL8987408

O=[N+]([O-])c1cc2c(c([N+](=O)[O-])c1[N+](=O)[O-])C(=Nc1ccccc1)c1ccccc1-2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.44
HSP90AA1 P07900 3/20 0.43
CDK5 Q00535 2/20 0.43
CDK5R1 Q15078 2/20 0.43
ALDH1A1 P00352 4/20 0.42
MAPK1 P28482 3/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
STAT6 P42226 1/20 0.42
HIF1A Q16665 1/20 0.42
PHLPP2 Q6ZVD8 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 2/20 0.38
MAPT P10636 3/20 0.38
NCOA1 Q15788 1/20 0.38
NCOA3 Q9Y6Q9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7733450 0.87 HSP90AA1 (0.52) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL18138415 0.84 HSP90AA1 (0.46) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL9152162 0.83 HSP90AA1 (0.48) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL9155532 0.80 HSP90AA1 (0.40) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL6523937 0.78 ALDH1A1 (0.47) HSP90AA1CDK5CDK5R1ALDH1A1MAPK1
SCHEMBL149722 0.76 ALDH1A1 (0.62) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL27548148 0.71 ALDH1A1 (0.55) ALDH1A1MAPK1TP53CYP1A2CYP3A4
SCHEMBL11786497 0.71 MAPT (0.68) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL11786504 0.71 MAPT (0.68) SMN1; SMN2HSP90AA1CDK5CDK5R1ALDH1A1
SCHEMBL11424411 0.70 ALDH1A1 (0.62) SMN1; SMN2ALDH1A1MAPK1TP53CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0718278-A2 Derivatives of N-phenyl-trinitrofluorenonimine and electron transporting material MITA INDUSTRIAL CO., LTD. (JP) 1996-06-26 EP disclosed