Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28890292 | 0.85 | CYP3A4 (0.50) | CYP3A4ACHEFLT3HPGDNR1H2 | |
| SCHEMBL16191696 | 0.77 | FLT3 (0.58) | CYP3A4ACHEFLT3HPGDPOLB | |
| SCHEMBL16191700 | 0.77 | FLT3 (0.58) | CYP3A4ACHEFLT3HPGDPOLB | |
| SCHEMBL725269 | 0.76 | CYP3A4 (0.77) | CYP3A4ACHEHPGDNR1H2NR1H3 | |
| SCHEMBL29018163 | 0.74 | SLC5A1 (0.56) | CYP3A4ACHEFLT3MEN1PTGS1 | |
| SCHEMBL29018300 | 0.72 | PTGS1 (0.55) | CYP3A4ACHEPTGS1PTGS2SLC5A1 | |
| SCHEMBL28672295 | 0.71 | FLT3 (0.52) | CYP3A4FLT3HPGD | |
| SCHEMBL28672294 | 0.71 | FLT3 (0.52) | CYP3A4FLT3HPGD | |
| SCHEMBL16191521 | 0.71 | FLT3 (0.52) | CYP3A4FLT3HPGDKMT2AMAPT | |
| SCHEMBL28599428 | 0.70 | CYP3A4 (0.62) | CYP3A4ACHEHPGDNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197787-A1 | Heat shock protein 90 inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | CYP3A4 4152/4885ACHE 4824/4885FLT3 3546/4885 |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | HSP90AB2P, HSPH1, HSP90AA1 | CYP3A4 4166/4885ACHE 4820/4885FLT3 3723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.