Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425195 | 0.83 | TSHR (0.51) | TSHRRECQLKMT2AALDH1A1HTT | |
| SCHEMBL1830778 | 0.82 | HDAC3 (0.63) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8987604 | 0.82 | KMT2A (0.64) | SMN1; SMN2KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL8987696 | 0.81 | HDAC3 (0.46) | SMN1; SMN2TSHRALDH1A1HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL8987622 | 0.80 | HDAC3 (0.61) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8987493 | 0.80 | FFAR1 (0.47) | SMN1; SMN2TSHRKMT2AALDH1A1HDAC3 | |
| SCHEMBL5024832 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AALDH1A1HDAC3HDAC1 | |
| SCHEMBL6508483 | 0.79 | TSHR (0.45) | SMN1; SMN2TSHRRECQLKMT2AALDH1A1 | |
| SCHEMBL15862571 | 0.79 | HDAC3 (0.58) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7829175 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AALDH1A1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | claimed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | claimed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | claimed |
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |