Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987627 | 0.86 | CYP2C9 (0.47) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL9170122 | 0.85 | LTB4R (0.50) | HDAC3HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL1830778 | 0.84 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987558 | 0.83 | SIGMAR1 (0.63) | ALDH1A1TMEM97SIGMAR1DPP7HTT | |
| SCHEMBL8987683 | 0.83 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| Hydrochloric Acid SCHEMBL8987622 | 0.82 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987493 | 0.82 | FFAR1 (0.47) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987490 | 0.81 | SMN1; SMN2 (0.53) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL15862571 | 0.80 | HDAC3 (0.58) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL9172532 | 0.79 | MEP1B (0.58) | ALDH1A1LTB4RHTTFFAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | claimed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | claimed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | claimed |
| JP-2032029-A | — | — | None | — | — | JP | disclosed |
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| JP-H0232029-A | THERAPEUTIC MEDICINE FOR DEPRESSION OR SENILE DEMENTIA | JOHN WYETH & BROS LTD | 1990-02-01 | — | — | JP | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |