Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7617011 | 0.80 | MAPK8 (0.30) | MAPK8DYRK1ACLK4DYRK1BMAP2K1 | |
| SCHEMBL4231524 | 0.80 | MAPK8 (0.30) | MAPK8DYRK1ACLK4DYRK1BMAP2K1 | |
| SCHEMBL7616758 | 0.80 | MAPK8 (0.33) | MAPK8DYRK1ACLK4DYRK1BMAP2K1 | |
| SCHEMBL2561874 | 0.77 | CYP2A6 (0.31) | — | |
| SCHEMBL9486314 | 0.76 | MAPK8 (0.31) | MAPK8DYRK1ACLK4DYRK1BMAP2K1 | |
| SCHEMBL27589630 | 0.75 | — | — | |
| SCHEMBL825561 | 0.72 | BRD4 (0.32) | — | |
| Benzene SCHEMBL26606838 | 0.68 | MAPK8 (0.36) | MAPK8DYRK1ACLK4DYRK1BMAP2K1 | |
| SCHEMBL3763 | 0.67 | — | — | |
| SCHEMBL9443405 | 0.66 | CRBN (0.35) | MAPK8DYRK1ACLK4DYRK1BMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719271-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007917-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-23 | — | — | WO | disclosed |