⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335180 | 0.71 | — | — | |
| SCHEMBL8624319 | 0.67 | CA2 (0.33) | — | |
| SCHEMBL25178167 | 0.67 | CYP2A6 (0.34) | — | |
| Water SCHEMBL28189314 | 0.66 | CA2 (0.69) | — | |
| SCHEMBL2503454 | 0.66 | CA2 (0.69) | — | |
| SCHEMBL45942 | 0.66 | CA2 (0.69) | — | |
| Water SCHEMBL28254092 | 0.66 | CA2 (0.69) | — | |
| SCHEMBL27567478 | 0.63 | CA2 (0.65) | — | |
| SCHEMBL28829194 | 0.63 | CA2 (0.65) | — | |
| Ammonia Solution, Strong SCHEMBL27405382 | 0.63 | CA2 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230056559-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2023-02-23 | — | — | US | disclosed |
| EP-3919492-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | Medshine Discovery Inc. (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020156453-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | 南京明德新药研发有限公司 | 2020-08-06 | — | — | WO | disclosed |
| WO-2012006202-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
| EP-0607803-B1 | Process for the preparation of 6-amino-3-pyridinecarbonitriles | BAYER AG (DE) | 1996-07-10 | — | — | EP | disclosed |
| US-5480995-A | Process for the preparation of 6-amino-nicotinonitriles | BAYER AKTIENGESELLSCHAFT (DE) | 1996-01-02 | — | — | US | disclosed |
| EP-0607803-A1 | Process for the preparation of 6-amino-3-pyridinecarbonitriles | BAYER AG (DE) | 1994-07-27 | — | — | EP | disclosed |