Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10431879 | 0.88 | BRD4 (0.40) | CDK1CDK4CCND1CDK2BRD4 | |
| SCHEMBL8989418 | 0.85 | BRD4 (0.42) | CDK1CDK4CCND1CDK2BRD4 | |
| SCHEMBL12415572 | 0.83 | KDM4E (0.53) | CDK1CDK4CCND1CDK2KDM4E | |
| SCHEMBL28528412 | 0.79 | KAT2B (0.46) | CDK1CDK4CCND1CDK2BRD4 | |
| SCHEMBL30776204 | 0.79 | GRIK1 (0.52) | BRD4ATAD2KDM4EHSD17B10NSD2 | |
| SCHEMBL4497370 | 0.77 | AURKA (0.42) | CDK1CDK4CCND1CDK2BRD4 | |
| SCHEMBL377833 | 0.77 | SIRT2 (0.56) | CDK1CDK4CCND1CDK2BRD4 | |
| SCHEMBL8989435 | 0.77 | KDM1A (0.50) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL10975531 | 0.75 | KMT2A (0.47) | CDK1CDK4CCND1CDK2BRD4 | |
| SCHEMBL28111714 | 0.74 | GRIK1 (0.41) | KDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383579-B1 | N-Phenyl-N-(4-piperidinyl)amides useful as analgesics | GLAXO WELLCOME INC (US) | 1996-07-17 | — | — | EP | disclosed |
| US-5019583-A | N-phenyl-N-(4-piperidinyl)amides useful as analgesics | GLAXO INC. (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0383579-A1 | N-Phenyl-N-(4-piperidinyl)amides useful as analgesics | GLAXO WELLCOME INC. (US) | 1990-08-22 | — | — | EP | disclosed |