Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 5/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30776204 | 0.86 | GRIK1 (0.52) | AURKARPS6KB1BRD4ATAD2SIRT2 | |
| SCHEMBL377833 | 0.84 | SIRT2 (0.56) | AURKARPS6KB1BRD4ATAD2SIRT2 | |
| SCHEMBL28528412 | 0.83 | KAT2B (0.46) | AURKARPS6KB1BRD4ATAD2SIRT2 | |
| SCHEMBL10975531 | 0.82 | KMT2A (0.47) | AURKARPS6KB1BRD4ATAD2NSD2 | |
| SCHEMBL12415572 | 0.82 | KDM4E (0.53) | CDK1CDK4CCND1CDK2 | |
| SCHEMBL8989418 | 0.81 | BRD4 (0.42) | AURKARPS6KB1BRD4ATAD2SIRT2 | |
| SCHEMBL14417232 | 0.78 | CHEK1 (0.48) | AURKARPS6KB1BRD4ATAD2SIRT2 | |
| SCHEMBL8989463 | 0.77 | CDK1 (0.43) | AURKARPS6KB1BRD4ATAD2SIRT2 | |
| SCHEMBL30776206 | 0.77 | GRIK1 (0.53) | AURKARPS6KB1BRD4ATAD2GRIK1 | |
| SCHEMBL27538853 | 0.76 | RPS6KB1 (0.56) | AURKARPS6KB1BRD4ATAD2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576105-B2 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2009-08-18 | — | — | US | disclosed |
| US-7576105-B2 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2009-08-18 | — | — | US | disclosed |
| US-7576105-B2 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | JANSSEN PHARMACEUTICA, NV (BE) | 2009-08-18 | — | — | US | disclosed |
| US-20060106066-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | BAXTER ELLEN W | 2006-05-18 | — | — | US | disclosed |
| US-20060106066-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | BAXTER ELLEN W | 2006-05-18 | — | — | US | disclosed |
| US-20060106066-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | BAXTER ELLEN W | 2006-05-18 | — | — | US | disclosed |
| WO-2004035541-A1 | BENZYL SUBSTITUTED (PIPERIDIN-4-YL) AMINOBENZAMIDO DERIVATIVES AS DELTA-OPIOD RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004035541-A1 | BENZYL SUBSTITUTED (PIPERIDIN-4-YL) AMINOBENZAMIDO DERIVATIVES AS DELTA-OPIOD RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-04-29 | — | — | WO | disclosed |
| US-20040082612-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | JANSSEN PHARMACEUTICALS N.V. (BE) | 2004-04-29 | — | — | US | disclosed |
| US-20040082612-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | JANSSEN PHARMACEUTICALS N.V. (BE) | 2004-04-29 | — | — | US | disclosed |
| US-20040082612-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | JANSSEN PHARMACEUTICALS N.V. (BE) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106066-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | OPRD1, OPRK1, OPRM1 | AURKA 3189/4885RPS6KB1 428/4885BRD4 140/4885 |
| US-20040082612-A1 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives | OPRD1, OPRK1, OPRM1 | AURKA 3189/4885RPS6KB1 428/4885BRD4 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.