Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719710 | 0.86 | APLNR (0.58) | APLNRTP53ALDH1A1MAPTCA12 | |
| SCHEMBL18301920 | 0.83 | APLNR (0.54) | APLNRTP53ALDH1A1MAPTCA12 | |
| SCHEMBL31172821 | 0.77 | APLNR (0.66) | APLNRALDH1A1MAPTCA12CA1 | |
| SCHEMBL805138 | 0.77 | APLNR (0.66) | APLNRALDH1A1MAPTCA12CA1 | |
| SCHEMBL1530735 | 0.77 | APLNR (0.65) | APLNRTP53ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5984089 | 0.77 | KDM4E (0.54) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL2338048 | 0.76 | HSD17B10 (0.51) | APLNRTP53ALDH1A1MAPTSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL266597 | 0.76 | APLNR (0.63) | APLNRALDH1A1MAPTCA12CA1 | |
| 1,2,4-Trimethoxybenzene SCHEMBL2496227 | 0.76 | CA12 (0.75) | TP53ALDH1A1MAPTCA12CA1 | |
| SCHEMBL590943 | 0.76 | APLNR (0.63) | APLNRALDH1A1MAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578633-A | VASOPRESSIN AND OXYTOCIN ANTAGONISTS | SANOFI (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |
| US-5397801-A | Affinity for vasopressin and ocytocin receptors; disorders of nervous, cardiovascular and gastrointestinal systems | SANOFI (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5338755-A | Have affinity for vasopressin and ocytocin receptors; intermediates for drugs that act on central nervous system | ELF SANOFI (FR) | 1994-08-16 | — | — | US | disclosed |