Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493223 | 0.79 | CHRM2 (0.37) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL2498342 | 0.79 | CHRM2 (0.37) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL1268620 | 0.73 | NR1H2 (0.33) | NR1H2NR1H3CHRM2CHRM1CHRM3 | |
| SCHEMBL2119472 | 0.72 | CHRM2 (0.36) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL875047 | 0.72 | CHRM2 (0.36) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL2933886 | 0.71 | NR1H2 (0.47) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL18811768 | 0.71 | NR1H2 (0.47) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL18811702 | 0.71 | NR1H2 (0.47) | NR1H2CHRM2CHRM1CHRM3RORC | |
| SCHEMBL24070869 | 0.70 | CHRM2 (0.35) | NR1H2NR1H3CHRM2CHRM1CHRM3 | |
| SCHEMBL8990005 | 0.70 | NR1H2 (0.33) | NR1H2NR1H3CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578633-A | VASOPRESSIN AND OXYTOCIN ANTAGONISTS | SANOFI (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |
| US-5397801-A | Affinity for vasopressin and ocytocin receptors; disorders of nervous, cardiovascular and gastrointestinal systems | SANOFI (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5338755-A | Have affinity for vasopressin and ocytocin receptors; intermediates for drugs that act on central nervous system | ELF SANOFI (FR) | 1994-08-16 | — | — | US | disclosed |