Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 6/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990015 | 0.87 | MAP4K4 (0.51) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL4301894 | 0.87 | MAP4K4 (0.51) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL8990049 | 0.85 | MAP4K4 (0.49) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL4296453 | 0.82 | MAP4K4 (0.53) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL8990055 | 0.82 | MAPK14 (0.47) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL4298123 | 0.81 | MAP4K4 (0.50) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL4302423 | 0.79 | MAP4K4 (0.48) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL13958854 | 0.79 | MAPK9 (0.34) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL3246874 | 0.79 | CSNK1D (0.53) | MAP4K4CSNK1DPRKD2MAPK9EGFR | |
| SCHEMBL4300074 | 0.77 | MAP4K4 (0.60) | MAP4K4CSNK1DPRKD2MAPK9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188083-B2 | Triazolopyridazines | ABBOTT LABORATORIES (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188083-B2 | Triazolopyridazines | ABBOTT LABORATORIES (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090270402-A1 | Novel triazolopyridazines | ABBVIE INC. | 2009-10-29 | — | — | US | disclosed |
| US-20090270402-A1 | Novel triazolopyridazines | ABBVIE INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270402-A1 | Novel triazolopyridazines | MAP3K5, MAP3K1, MAP3K2 | MAP4K4 24/4885CSNK1D 173/4885PRKD2 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.