Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 8/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4298568 | 0.95 | MAPK14 (0.47) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL8990049 | 0.92 | MAP4K4 (0.49) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL8990015 | 0.90 | MAP4K4 (0.51) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL4301894 | 0.88 | MAP4K4 (0.51) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL4302423 | 0.87 | MAP4K4 (0.48) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL8989836 | 0.86 | MAP4K4 (0.48) | CSNK1DMAP4K4PRKD2EGFRMAPK9 | |
| SCHEMBL4298123 | 0.85 | MAP4K4 (0.50) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL13959492 | 0.83 | MAPK14 (0.38) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL8990029 | 0.82 | MAP4K4 (0.53) | MAPK14CSNK1DMAP4K4PRKD2EGFR | |
| SCHEMBL4301613 | 0.78 | MAPK14 (0.41) | MAPK14CSNK1DMAP4K4PRKD2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188083-B2 | Triazolopyridazines | ABBOTT LABORATORIES (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188083-B2 | Triazolopyridazines | ABBOTT LABORATORIES (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090270402-A1 | Novel triazolopyridazines | ABBVIE INC. | 2009-10-29 | — | — | US | disclosed |
| US-20090270402-A1 | Novel triazolopyridazines | ABBVIE INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270402-A1 | Novel triazolopyridazines | MAP3K5, MAP3K1, MAP3K2 | MAPK14 72/4885CSNK1D 173/4885MAP4K4 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.