Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677475 | 0.72 | CYP19A1 (0.40) | TSHRALOX15POLBCYP19A1 | |
| SCHEMBL11583404 | 0.69 | CYP19A1 (0.39) | TSHRALOX15POLBCYP19A1 | |
| SCHEMBL25236376 | 0.67 | POLB (0.36) | TSHRALOX15POLBCYP19A1 | |
| SCHEMBL19723785 | 0.67 | POLB (0.36) | TSHRALOX15POLBCYP19A1 | |
| SCHEMBL11041822 | 0.66 | MET (0.42) | TSHRALOX15CYP19A1 | |
| SCHEMBL11041827 | 0.66 | MET (0.42) | TSHRALOX15CYP19A1 | |
| SCHEMBL10704819 | 0.65 | CYP19A1 (0.39) | TSHRALOX15POLBCYP19A1 | |
| SCHEMBL10348295 | 0.65 | — | — | |
| SCHEMBL15908511 | 0.64 | CYP19A1 (0.35) | TSHRALOX15POLBCYP19A1 | |
| SCHEMBL2585385 | 0.64 | CYP19A1 (0.40) | CA12CA9TSHRALOX15POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563250-A | Cleavable conjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1996-10-08 | — | — | US | disclosed |
| US-5141648-A | Methods for isolating compounds using cleavable linker bound matrices | NEORX CORPORATION (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0318948-B1 | CLEAVABLE IMMUNOCONJUGATES FOR THE DELIVERY AND RELEASE OF AGENTS IN NATIVE FORM | NEORX CORPORATION (US) | 1992-08-19 | — | — | EP | disclosed |
| US-5017693-A | Methods for introducing a sulfhydryl amino or hydroxyl groups to a compound | NEORX CORPORATION (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0318948-A2 | Cleavable immunoconjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1989-06-07 | — | — | EP | disclosed |