Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990856 | 1.00 | TSHR (0.49) | TSHRDAOKIF11SLC6A4SLC6A3 | |
| SCHEMBL9425434 | 0.94 | TSHR (0.53) | TSHRKIF11SLC6A4ALDH1A1GRM2 | |
| SCHEMBL2056279 | 0.94 | TSHR (0.53) | TSHRKIF11SLC6A4ALDH1A1GRM2 | |
| SCHEMBL9062148 | 0.94 | TSHR (0.53) | TSHRDAOSLC6A4SLC6A3GPR84 | |
| SCHEMBL8990653 | 0.91 | TSHR (0.47) | TSHRDAOKIF11SLC6A4SLC6A3 | |
| SCHEMBL8990885 | 0.91 | TSHR (0.47) | TSHRDAOKIF11SLC6A4SLC6A3 | |
| SCHEMBL9425491 | 0.89 | TSHR (0.49) | TSHRDAOKIF11SLC6A4SLC6A3 | |
| SCHEMBL9060389 | 0.89 | TSHR (0.49) | TSHRDAOKIF11SLC6A4SLC6A3 | |
| SCHEMBL155707 | 0.88 | TSHR (0.58) | TSHRSLC6A4SLC6A3ALDH1A1LMNA | |
| SCHEMBL8990723 | 0.88 | RARB (0.46) | TSHRDAOKIF11SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496499-A | Biphenylethanes and liquid-crystalline phase | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-03-05 | — | — | US | disclosed |
| EP-0429558-B1 | DIPHENYLYLETHANES AND LIQUID CRYSTALLINE PHASE | MERCK PATENT GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |