Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | DRD4 | P21917 | 7/20 | 0.37 |
| ▸ | DRD3 | P35462 | 7/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990780 | 0.94 | GHSR (0.56) | GHSRDRD2DRD4DRD3KCNA5 | |
| SCHEMBL8990935 | 0.93 | GHSR (0.55) | GHSRDRD2DRD4DRD3KCNA5 | |
| SCHEMBL8990887 | 0.91 | GHSR (0.46) | GHSRKCNA5KCNH2OPRM1OPRK1 | |
| SCHEMBL8990941 | 0.91 | GHSR (0.62) | GHSRDRD2DRD4DRD3HTR1A | |
| SCHEMBL8990929 | 0.90 | GHSR (0.55) | GHSRDRD2DRD4DRD3KCNA5 | |
| SCHEMBL8990958 | 0.86 | GHSR (0.61) | GHSRDRD2DRD4DRD3KCNA5 | |
| SCHEMBL8990881 | 0.86 | GHSR (0.44) | GHSRDRD2DRD4DRD3KCNA5 | |
| SCHEMBL8990767 | 0.85 | GHSR (0.48) | GHSRDRD2DRD4DRD3KCNA5 | |
| SCHEMBL8990983 | 0.85 | GHSR (0.62) | GHSROPRM1OPRK1OPRL1 | |
| SCHEMBL8990822 | 0.84 | GHSR (0.55) | GHSRDRD2DRD4DRD3KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | claimed |
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |