Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758092 | 1.00 | POLB (0.46) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL10762058 | 0.87 | POLB (0.43) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL10763448 | 0.86 | POLB (0.46) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL8894148 | 0.84 | POLB (0.45) | POLBTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8991239 | 0.82 | POLB (0.49) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL10994030 | 0.81 | POLB (0.44) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL9781970 | 0.81 | POLB (0.50) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL9781964 | 0.81 | POLB (0.50) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL11120932 | 0.81 | POLB (0.50) | POLBTP53MEN1CYP1A2KMT2A | |
| SCHEMBL11105881 | 0.81 | POLB (0.48) | POLBTP53MEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419215-B1 | Process for preparing 4-substituted azetidinones | LILLY CO ELI (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5106475-A | Alkylating, deprotecting, electrolytic reduction; intermediate for beta-lactam antibiotics | ELI LILLY AND COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0419215-A2 | Process for preparing 4-substituted azetidinones | ELI LILLY AND COMPANY (US) | 1991-03-27 | — | — | EP | disclosed |
| EP-0163452-A1 | A novel process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones | ELI LILLY AND COMPANY (US) | 1985-12-04 | — | — | EP | disclosed |