Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781970 | 0.85 | POLB (0.50) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL9781964 | 0.85 | POLB (0.50) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL11120932 | 0.85 | POLB (0.50) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL10363227 | 0.84 | POLB (0.49) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL11105882 | 0.84 | TP53 (0.49) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL8991243 | 0.83 | MEN1 (0.47) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL10758092 | 0.82 | POLB (0.46) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL8991184 | 0.82 | POLB (0.46) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL8991285 | 0.82 | POLB (0.46) | POLBTP53MEN1KMT2ACYP1A2 | |
| SCHEMBL11105881 | 0.82 | POLB (0.48) | POLBTP53MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419215-B1 | Process for preparing 4-substituted azetidinones | LILLY CO ELI (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5106475-A | Alkylating, deprotecting, electrolytic reduction; intermediate for beta-lactam antibiotics | ELI LILLY AND COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0419215-A2 | Process for preparing 4-substituted azetidinones | ELI LILLY AND COMPANY (US) | 1991-03-27 | — | — | EP | disclosed |