Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895403 | 1.00 | PTGS2 (0.48) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8933397 | 0.93 | PTGS2 (0.50) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8893201 | 0.93 | PTGS2 (0.50) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8896290 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8933259 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8895401 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8991918 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8894338 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8991953 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 | |
| SCHEMBL8895775 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1CYP1A2CYP2C9ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0211670-B1 | DI-T-BUTYLPHENOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1990-05-09 | — | — | EP | disclosed |
| EP-0211670-A2 | Di-t-butylphenol compounds | ELI LILLY AND COMPANY (US) | 1987-02-25 | — | — | EP | disclosed |