Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 12/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | MPI | P34949 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991957 | 1.00 | IGF1R (0.56) | IGF1RCISD1MEN1KMT2AMAPT | |
| SCHEMBL8537140 | 0.81 | MEN1 (0.50) | IGF1RCISD1MEN1KMT2AMAPT | |
| SCHEMBL8537136 | 0.81 | MEN1 (0.50) | IGF1RCISD1MEN1KMT2AMAPT | |
| SCHEMBL8957287 | 0.79 | CYP1A2 (0.50) | IGF1RCISD1MEN1KMT2AMAPT | |
| SCHEMBL8537121 | 0.78 | CYP1A2 (0.51) | IGF1RCYP3A4CYP2B6 | |
| SCHEMBL8532780 | 0.78 | PTGS2 (0.56) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL8537123 | 0.78 | CYP1A2 (0.51) | IGF1RCYP3A4CYP2B6 | |
| SCHEMBL8532777 | 0.78 | PTGS2 (0.56) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL8532250 | 0.76 | CYP1A2 (0.40) | IGF1RCISD1MEN1KMT2AMAPT | |
| SCHEMBL8532254 | 0.76 | CYP1A2 (0.40) | IGF1RCISD1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | disclosed |