Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993053 | 0.82 | HCAR2 (0.42) | GPR119HCAR2NPC1RAB9AMEN1 | |
| SCHEMBL8992995 | 0.80 | GPR119 (0.47) | GPR119NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8992934 | 0.79 | GPR119 (0.47) | GPR119NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7900015 | 0.79 | NPC1 (0.44) | GPR119NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8992889 | 0.78 | HCAR2 (0.50) | GPR119HCAR2NPC1RAB9AMEN1 | |
| SCHEMBL13990623 | 0.76 | NPC1 (0.54) | HCAR2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11776811 | 0.72 | TLR8 (0.51) | GPR119NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9167852 | 0.72 | GPR119 (0.43) | GPR119NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9167829 | 0.72 | GPR119 (0.38) | GPR119NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20137287 | 0.70 | NPC1 (0.43) | GPR119NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |