Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27465439 | 0.74 | HSP90AA1 (0.43) | HSP90AA1SRD5A1SRD5A2SLC1A3SLC1A2 | |
| SCHEMBL11572533 | 0.71 | AKR1B1 (0.53) | HSP90AA1SRD5A1SRD5A2ALDH1A1KDM4E | |
| SCHEMBL22558151 | 0.71 | FFAR1 (0.46) | GPR17FFAR1FFAR4FBP1 | |
| Acetic Acid SCHEMBL28167102 | 0.70 | HSP90AA1 (0.57) | HSP90AA1SRD5A1SRD5A2SLC1A3SLC1A2 | |
| SCHEMBL8993313 | 0.69 | FFAR1 (0.40) | GPR17FFAR1ALDH1A1TP53RXRA | |
| SCHEMBL11681417 | 0.69 | AKR1B1 (0.52) | HSP90AA1SRD5A1SRD5A2SLC1A3SLC1A2 | |
| Acetic Acid SCHEMBL28536141 | 0.69 | HSP90AA1 (0.44) | HSP90AA1SRD5A1SRD5A2SLC1A3SLC1A2 | |
| SCHEMBL4699761 | 0.69 | FFAR1 (0.49) | GPR17FFAR1ALDH1A1TP53RXRA | |
| SCHEMBL32689799 | 0.69 | FFAR1 (0.49) | GPR17FFAR1ALDH1A1TP53RXRA | |
| SCHEMBL22660982 | 0.69 | NPC1 (0.44) | SRD5A2FFAR1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519043-A | ANTIINFLAMMATORY AGENTS WITH AMIDE, CARBAMATE OR THIOCARBAMATE GROUPS ON FLUORENE AND BENZENE | SCIOS NOVA INC. (US) | 1996-05-21 | — | — | US | disclosed |
| US-5472973-A | Non-steroidal antiinflammatory agents | SCIOS NOVA INC. (US) | 1995-12-05 | — | — | US | disclosed |
| WO-1993011764-A1 | FLUORENYL DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCIOS NOVA INC. (US) | 1993-06-24 | — | — | WO | disclosed |