Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.40 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993268 | 0.69 | HSP90AA1 (0.53) | FFAR1GPR17PPARGKDM4EHPGD | |
| SCHEMBL30633032 | 0.68 | S100A4 (0.41) | TP53HTT | |
| SCHEMBL8993316 | 0.68 | S100A4 (0.41) | TP53HTT | |
| SCHEMBL32689799 | 0.66 | FFAR1 (0.49) | FFAR1GPR17RXRARXRBALDH1A1 | |
| SCHEMBL4699761 | 0.66 | FFAR1 (0.49) | FFAR1GPR17RXRARXRBALDH1A1 | |
| SCHEMBL1590066 | 0.63 | GPR17 (0.57) | FFAR1GPR17RXRARXRBFFAR4 | |
| SCHEMBL2109135 | 0.63 | AKR1B1 (0.63) | FFAR1GPR17KDM4ESLC22A12 | |
| SCHEMBL30567601 | 0.63 | PDPK1 (0.59) | FFAR1GPR17PPARGHPGDALDH1A1 | |
| SCHEMBL586345 | 0.63 | PDPK1 (0.59) | FFAR1GPR17PPARGHPGDALDH1A1 | |
| SCHEMBL2687868 | 0.62 | CYP2A6 (0.40) | ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519043-A | ANTIINFLAMMATORY AGENTS WITH AMIDE, CARBAMATE OR THIOCARBAMATE GROUPS ON FLUORENE AND BENZENE | SCIOS NOVA INC. (US) | 1996-05-21 | — | — | US | disclosed |
| US-5472973-A | Non-steroidal antiinflammatory agents | SCIOS NOVA INC. (US) | 1995-12-05 | — | — | US | disclosed |
| WO-1993011764-A1 | FLUORENYL DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCIOS NOVA INC. (US) | 1993-06-24 | — | — | WO | disclosed |