Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.32 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993495 | 0.84 | PIM1 (0.37) | PIM1PPARAJAK2JAK1JAK3 | |
| SCHEMBL18695385 | 0.77 | PIK3CD (0.38) | JAK2 | |
| SCHEMBL29438061 | 0.77 | PIK3CD (0.38) | JAK2 | |
| SCHEMBL13450565 | 0.75 | CYP2A6 (0.43) | PIM1PPARAJAK2JAK1JAK3 | |
| SCHEMBL5387804 | 0.75 | PIM1 (0.39) | PIM1PPARAJAK2JAK1JAK3 | |
| SCHEMBL8993437 | 0.74 | F2RL1 (0.40) | PIM1PPARACYP1A2GRM5TDP1 | |
| SCHEMBL13439540 | 0.71 | F2RL1 (0.40) | PIM1PPARAJAK2JAK1JAK3 | |
| SCHEMBL5383451 | 0.71 | TRIM24 (0.43) | PIM1PPARAJAK2JAK1JAK3 | |
| SCHEMBL884496 | 0.70 | KCNA5 (0.55) | PIM1PPARATDP1 | |
| SCHEMBL3083160 | 0.70 | JAK2 (0.44) | PIM1JAK2JAK1JAK3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |