Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993439 | 0.84 | PIM1 (0.37) | PIM1F2RL1PPARAJAK2JAK1 | |
| SCHEMBL30832971 | 0.76 | KDM4E (0.48) | L3MBTL1RUNX1KDM4ENPC1LMNA | |
| SCHEMBL7160604 | 0.76 | KDM4E (0.48) | L3MBTL1RUNX1KDM4ENPC1LMNA | |
| SCHEMBL8993493 | 0.75 | ALDH1A1 (0.46) | PIM1L3MBTL1KDM4EF2RL1PPARA | |
| SCHEMBL5387804 | 0.75 | PIM1 (0.39) | PIM1F2RL1PPARAJAK2JAK1 | |
| SCHEMBL13450565 | 0.75 | CYP2A6 (0.43) | PIM1F2RL1PPARAJAK2JAK1 | |
| SCHEMBL13439540 | 0.71 | F2RL1 (0.40) | PIM1F2RL1PPARAJAK2JAK1 | |
| SCHEMBL5383451 | 0.71 | TRIM24 (0.43) | PIM1L3MBTL1KDM4ENPC1LMNA | |
| SCHEMBL7036968 | 0.70 | KDM4E (0.48) | L3MBTL1KDM4ENPC1LMNAGAA | |
| SCHEMBL30098846 | 0.70 | KDM4E (0.48) | L3MBTL1KDM4ENPC1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |