Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295731 | 0.92 | HDAC1 (0.53) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL295732 | 0.92 | HDAC1 (0.53) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL8993555 | 0.88 | PKM (0.58) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL295857 | 0.88 | HDAC1 (0.43) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL295856 | 0.88 | HDAC1 (0.43) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL3136222 | 0.87 | HDAC1 (0.54) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL296513 | 0.87 | HDAC1 (0.54) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL3141625 | 0.87 | HDAC1 (0.51) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL296512 | 0.87 | HDAC1 (0.54) | PKMHDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL3141637 | 0.87 | HDAC1 (0.51) | PKMHDAC1HDAC6HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969401-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2015-03-03 | — | — | US | disclosed |
| US-8815855-B2 | N-sulphonylpyrroles and their use as histone deacetylase inhibitors | 4SC AG (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | ALTANA PHARMA AG (DE) | 2013-03-28 | — | — | US | disclosed |
| US-8399505-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8399505-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8232297-B2 | Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles | 4SC AG (DE) | 2012-07-31 | — | — | US | disclosed |
| US-8232297-B2 | Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles | 4SC AG (DE) | 2012-07-31 | — | — | US | disclosed |
| US-8188138-B2 | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors | 4SC AG (DE) | 2012-05-29 | — | — | US | disclosed |
| US-8188138-B2 | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors | 4SC AG (DE) | 2012-05-29 | — | — | US | disclosed |
| US-8067615-B2 | Sulphonylpyrroles | 4SC AG (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20100261721-A1 | Novel Sulphonylpyrroles | MAIER THOMAS | 2010-10-14 | — | — | US | disclosed |
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | MAIER THOMAS | 2010-03-25 | — | — | US | disclosed |
| US-7666868-B2 | e.g. N-Hydroxy-3-{1-[4-(1-methyl-1H-indol-5-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide; antiproliferative, anticarcinogenic, antiinflammatory, neuroleptic agent, autoimmune disorders | 4SC AG (DE) | 2010-02-23 | — | — | US | disclosed |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | NYCOMED GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | NYCOMED GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | NYCOMED GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | NYCOMED GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20080176848-A1 | e.g. N-Hydroxy-3-{1-[4-(1-methyl-1H-indol-5-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide; antiproliferative, anticarcinogenic, antiinflammatory, neuroleptic agent, autoimmune disorders | NYCOMED GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
| US-20070184979-A1 | Novel sulfonylpyrroles | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
| US-20070184979-A1 | Novel sulfonylpyrroles | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | PKM 1330/4885HDAC1 1/4885HDAC6 8/4885 |
| US-20070184979-A1 | Novel sulfonylpyrroles | HDAC1, HDAC4, HDAC3 | PKM 563/4885HDAC1 1/4885HDAC6 8/4885 |
| US-20080176848-A1 | e.g. N-Hydroxy-3-{1-[4-(1-methyl-1H-indol-5-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide; antiproliferative, anticarcinogenic, antiinflammatory, neuroleptic agent, autoimmune disorders | HDAC1, H1-3, HDAC2 | PKM 3999/4885HDAC1 1/4885HDAC6 17/4885 |
| US-20100261721-A1 | Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | PKM 869/4885HDAC1 1/4885HDAC6 7/4885 |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC2 | PKM 1062/4885HDAC1 1/4885HDAC6 5/4885 |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | HDAC3, HDAC1, HDAC2 | PKM 726/4885HDAC1 2/4885HDAC6 7/4885 |
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC2 | PKM 1305/4885HDAC1 1/4885HDAC6 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.