Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733073 | 0.72 | PTGES2 (0.49) | PTGES2PTGS2GRM2 | |
| SCHEMBL8993537 | 0.65 | — | — | |
| SCHEMBL8993599 | 0.65 | PTGS2 (0.49) | PTGS2PDE3BPDE3AKIT | |
| SCHEMBL30270503 | 0.62 | PTGS2 (0.40) | PTGS2PDE3BPDE3A | |
| SCHEMBL10361729 | 0.60 | PTGS2 (0.36) | PTGES2PTGS2 | |
| SCHEMBL10758610 | 0.60 | PTGS2 (0.47) | PTGES2PTGS2GRM2 | |
| SCHEMBL16864072 | 0.59 | PTGS2 (0.33) | PTGS2 | |
| SCHEMBL7641695 | 0.59 | PSMB5 (0.43) | PTGS2GRM2 | |
| SCHEMBL10130412 | 0.58 | CSF1R (0.43) | GRM2 | |
| SCHEMBL28758944 | 0.58 | PTGS2 (0.51) | PTGS2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | claimed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | claimed |