SCHEMBL8993756

SCHEMBL8993756

COc1cc2ccc(S(=O)(=O)NC3CCCN(C(Cc4ccc(C(=N)N)cc4)C(=O)N4CCCC4)C3=O)cc2cc1OC

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F2 P00734 7/20 0.58
PRSS1 P07477 5/20 0.58
PRSS2 P07478 3/20 0.58
PRSS3 P35030 3/20 0.58
F10 P00742 16/20 0.56
PLG P00747 2/20 0.49
PROC P04070 2/20 0.49
PLAT P00750 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8993720 0.99 F2 (0.57) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993836 0.96 F10 (0.59) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993699 0.96 F10 (0.59) F2PRSS1PRSS2PRSS3F10
Iodide SCHEMBL8993774 0.95 F10 (0.59) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993716 0.94 F10 (0.54) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993757 0.93 F10 (0.65) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993703 0.93 F10 (0.62) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993698 0.93 F10 (0.59) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993788 0.90 F10 (0.57) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993753 0.90 F10 (0.56) F2PRSS1PRSS2PRSS3F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489583-A FOR TREATING OR PREVENTING THROMBOSIS BASF AKTIENGESELLSCHAFT (DE) 1996-02-06 US disclosed