Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387398 | 0.71 | SMN1; SMN2 (0.44) | ALDH1A1KMT2ACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL32687970 | 0.69 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1HIF1ASMN1; SMN2 | |
| SCHEMBL17827822 | 0.69 | SMN1; SMN2 (0.47) | ALDH1A1KMT2AMEN1HIF1ACRHBP | |
| SCHEMBL11825534 | 0.69 | TSHR (0.46) | ALDH1A1LMNAL3MBTL1KDM4EGAA | |
| SCHEMBL5378566 | 0.68 | HRH4 (0.42) | KMT2ACRHBPCRHR2SMN1; SMN2HRH4 | |
| SCHEMBL5365792 | 0.68 | KDM4E (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL32688089 | 0.68 | PIK3CA (0.48) | PRKDCAKT1 | |
| SCHEMBL25360705 | 0.67 | PIK3CA (0.51) | PRKDCAKT1 | |
| SCHEMBL5791348 | 0.67 | SMN1; SMN2 (0.68) | ALDH1A1KMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL15274303 | 0.66 | ITGA2B (0.44) | ALDH1A1KMT2AMEN1HIF1ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724573-A1 | PYRIMIDINONES AS ANTIARTHRITIC AND ANTI-INFLAMMATORIES | PHARMACIA & UPJOHN COMPANY (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011235-A1 | PYRIMIDINONES AS ANTIARTHRITIC AND ANTI-INFLAMMATORIES | THE UPJOHN COMPANY (US) | 1995-04-27 | — | — | WO | disclosed |