Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994536 | 1.00 | ACE (0.52) | ACELMNASMN1; SMN2 | |
| SCHEMBL8994537 | 1.00 | ACE (0.52) | ACELMNASMN1; SMN2 | |
| SCHEMBL7284494 | 0.89 | ACE (0.45) | ACE | |
| SCHEMBL7284487 | 0.89 | ACE (0.45) | ACE | |
| SCHEMBL9247684 | 0.89 | ACE (0.44) | ACELMNASMN1; SMN2 | |
| SCHEMBL8994535 | 0.89 | ACE (0.44) | ACELMNASMN1; SMN2 | |
| SCHEMBL8994542 | 0.89 | ACE (0.44) | ACELMNASMN1; SMN2 | |
| SCHEMBL8994547 | 0.83 | ACE (0.54) | ACELMNASMN1; SMN2 | |
| SCHEMBL9289142 | 0.83 | ACE (0.54) | ACELMNASMN1; SMN2 | |
| SCHEMBL7285065 | 0.80 | DPP4 (0.41) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5401760-A | Thiazoline derivative for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| US-5212191-A | Thiazoline derivatives for treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| US-5053414-A | Thiazolidine derivatives, enzyme inhibitors; amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |