Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168496 | 0.86 | PTGS2 (0.69) | PTGS2PTGS1PDE3A | |
| SCHEMBL14345230 | 0.82 | PTGS2 (0.65) | PTGS2PTGS1PDE3A | |
| SCHEMBL14345129 | 0.82 | PTGS2 (0.65) | PTGS2PTGS1PDE3A | |
| Mofezolac SCHEMBL151701 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1PDE3A | |
| SCHEMBL23410810 | 0.80 | PTGS2 (0.62) | PTGS2PTGS1PDE3APTGDR2 | |
| Mofezolac SCHEMBL5398805 | 0.80 | PTGS2 (0.97) | PTGS2PTGS1PDE3A | |
| SCHEMBL6167767 | 0.78 | PTGS2 (0.63) | PTGS2PTGS1PDE3A | |
| SCHEMBL4881634 | 0.77 | PTGS2 (0.77) | PTGS2PTGS1PDE3A | |
| SCHEMBL6170017 | 0.77 | PTGS2 (0.63) | PTGS2PTGS1PDE3A | |
| SCHEMBL5698463 | 0.77 | PTGS2 (0.63) | PTGS2PTGS1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725777-A1 | PROCESS FOR PREPARING 3,4-DIARYL-5-ISOXAZOLYL ACETIC ACID DERIVATIVES | F. JOH. KWIZDA GESELLSCHAFT M.B.H. (AT) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011888-A1 | PROCESS FOR PREPARING 3,4-DIARYL-5-ISOXAZOLYL ACETIC ACID DERIVATIVES | F. JOH. KWIZDA GESELLSCHAFT M.B.H. (AT) | 1995-05-04 | — | — | WO | disclosed |