Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994983 | 0.91 | LTB4R (0.59) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9118843 | 0.90 | LTB4R (0.61) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9116638 | 0.85 | LTB4R (0.65) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9119933 | 0.83 | LTB4R (0.61) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9120857 | 0.82 | LTB4R (0.61) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9120027 | 0.82 | LTB4R (0.60) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7711975 | 0.80 | LTB4R (0.72) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8994985 | 0.79 | LTB4R (0.68) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8994890 | 0.79 | LTB4R (0.71) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7932415 | 0.79 | POLB (0.75) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |