Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.69 |
| ▸ | HRH1 | P35367 | 2/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995219 | 0.98 | HRH3 (0.72) | HRH3HRH1HRH2KCNH2ACHE | |
| SCHEMBL7590612 | 0.92 | PSMB1 (0.63) | HRH3KCNH2KDM4E | |
| SCHEMBL1985063 | 0.90 | PSMB1 (0.66) | HRH3KCNH2KDM4E | |
| SCHEMBL3581930 | 0.86 | HRH3 (0.89) | HRH3HRH1KCNH2ACHERAD52 | |
| SCHEMBL491845 | 0.83 | HRH3 (0.97) | HRH3HRH1HRH2 | |
| SCHEMBL3578646 | 0.82 | HRH3 (0.90) | HRH3HRH1KCNH2ACHERAD52 | |
| SCHEMBL12050718 | 0.82 | HRH3 (0.96) | HRH3HRH1HRH2KCNH2 | |
| SCHEMBL491825 | 0.82 | HRH3 (1.00) | HRH3HRH1HRH2KCNH2ACHE | |
| SCHEMBL5855947 | 0.82 | HRH3 (0.94) | HRH3HRH1HRH2 | |
| SCHEMBL5276568 | 0.82 | HRH3 (1.00) | HRH3HRH1HRH2KCNH2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496844-A | Indole derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0639567-A1 | INDOLE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-22 | — | — | EP | disclosed |