Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389975 | 0.86 | ATM (0.50) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL10872929 | 0.82 | ERCC5 (0.48) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL1039390 | 0.78 | PTPN1 (0.59) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL10873037 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL10875509 | 0.77 | KDM4E (0.44) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL8938040 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL5571004 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL11388829 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL11823691 | 0.75 | ERCC5 (0.43) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 | |
| SCHEMBL3656317 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTL3MBTL1HPGDNCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496844-A | Indole derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0639567-A1 | INDOLE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-22 | — | — | EP | disclosed |