Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219736 | 0.88 | ATM (0.54) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL27343182 | 0.85 | ATM (0.52) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL9576012 | 0.82 | CES2 (0.56) | SMN1; SMN2MAPTHPGDALDH1A1RAB9A | |
| SCHEMBL28794417 | 0.80 | TSHR (0.61) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL6981701 | 0.80 | ATM (0.43) | SMN1; SMN2MAPTL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL11715994 | 0.80 | CES2 (0.54) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL27923092 | 0.77 | LOXL2 (0.50) | ATMCYP1A2CES2CES1ESR1 | |
| SCHEMBL8995230 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL1928026 | 0.76 | MAPT (1.00) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL13267783 | 0.76 | MAPT (1.00) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508273-A | ARALKYLPHOSPHONATES FOR OSTEOPOROSIS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |