Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 5/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | ESRRG | P62508 | 3/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PRF1 | P14222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12581415 | 0.83 | HSD17B1 (0.63) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL12980677 | 0.81 | APP (0.42) | HSD17B1HSD17B2RAB9AMEN1KMT2A | |
| SCHEMBL12562851 | 0.80 | HSD17B1 (0.61) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL12562796 | 0.80 | HSD17B1 (0.61) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL12562798 | 0.78 | HSD17B1 (0.59) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL12562792 | 0.78 | HSD17B1 (0.59) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL9933404 | 0.78 | HSD17B1 (0.59) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL12562788 | 0.78 | HSD17B1 (0.59) | HSD17B1HSD17B2RAB9AKDM4ENPC1 | |
| SCHEMBL15243106 | 0.77 | APP (0.44) | HSD17B1HSD17B2APPESR1ESR2 | |
| SCHEMBL4843589 | 0.77 | APP (0.39) | HSD17B1HSD17B2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041470-A1 | SGLT-2 INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2016-03-24 | — | — | WO | disclosed |
| EP-2530079-A1 | PHENYL C-GLUCOSIDE DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Tianjin Institute Of Pharmaceutical Research (CN) | 2012-12-05 | — | — | EP | disclosed |
| US-5580989-A | Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]-N | ABBOTT LABORATORIES (US) | 1996-12-03 | — | — | US | disclosed |
| EP-0726897-A1 | PROCESS FOR THE PREPARATION OF N-4- (SUBSTITUTED PHENYL)ALKYLTHIENYL]-, AND N-4- (SUBSTITUTED PHENYL)ALKYLFURYL]BUT-3-YN-2-YL]-N-HYDROXYUREA COMPOUNDS | Abbott Laboratories (US) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012589-A1 | PROCESS FOR THE PREPARATION OF N-4-[(SUBSTITUTED PHENYL)ALKYLTHIENYL]-, AND N-4-[(SUBSTITUTED PHENYL)ALKYLFURYL]BUT-3-YN-2-YL]-N-HYDROXYUREA COMPOUNDS | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |