Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 18/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.64 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.64 |
| ▸ | PRKX | P51817 | 1/20 | 0.64 |
| ▸ | NEK4 | P51957 | 1/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.64 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.64 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.64 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870913 | 1.00 | MAPKAPK2 (0.64) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL22191310 | 0.82 | HTR7 (0.58) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL17920542 | 0.79 | MAPKAPK2 (0.80) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL4365652 | 0.79 | MAPKAPK2 (1.00) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL4364169 | 0.79 | MAPKAPK2 (1.00) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL4368075 | 0.79 | MAPKAPK2 (1.00) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL4366770 | 0.78 | MAPKAPK2 (0.72) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL4365525 | 0.74 | MAPKAPK2 (0.76) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL4371397 | 0.72 | MAPKAPK2 (0.72) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 | |
| SCHEMBL16102053 | 0.72 | MAPKAPK2 (0.72) | MAPKAPK2AURKBPDGFRACSNK1G1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532245-A | TO REDUCE SMOOTH MUSCLE CONTRACTIONS; TREATMENT FOR URINARY INCONTINENCE, IRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-02 | — | — | US | claimed |