Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.58 |
| ▸ | SNCA | P37840 | 12/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996669 | 1.00 | SIGMAR1 (0.58) | SIGMAR1SNCAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6154735 | 0.80 | SIGMAR1 (0.48) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8996675 | 0.73 | SIGMAR1 (1.00) | SIGMAR1SNCAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29537463 | 0.73 | SNCA (0.81) | SIGMAR1SNCA | |
| SCHEMBL5574066 | 0.72 | APP (0.63) | SIGMAR1TRPA1APPNFE2L2 | |
| SCHEMBL30533683 | 0.72 | APP (0.63) | SIGMAR1TRPA1APPNFE2L2 | |
| SCHEMBL5574063 | 0.72 | APP (0.63) | SIGMAR1TRPA1APPNFE2L2 | |
| SCHEMBL9440881 | 0.72 | SIGMAR1 (0.59) | SIGMAR1SNCAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL10006568 | 0.71 | SNCA (0.56) | SIGMAR1SNCA | |
| SCHEMBL10006565 | 0.71 | SNCA (0.56) | SIGMAR1SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0532642-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0532642-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018868-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) | 1991-12-12 | — | — | WO | disclosed |