Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 16/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6717396 | 0.78 | EPHX2 (0.48) | EPHX2 | |
| SCHEMBL6155754 | 0.75 | SIGMAR1 (0.55) | EPHX2LMNAMAPTNPSR1 | |
| SCHEMBL6719597 | 0.74 | CNR2 (0.45) | EPHX2LMNAMAPTNPSR1 | |
| Guanidine SCHEMBL9516168 | 0.72 | SIGMAR1 (0.56) | EPHX2 | |
| SCHEMBL6727849 | 0.72 | EPHX2 (0.41) | EPHX2 | |
| SCHEMBL18423981 | 0.71 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL30294791 | 0.71 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL18464994 | 0.71 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL6158255 | 0.70 | SIGMAR1 (0.53) | EPHX2MAPTNPSR1 | |
| SCHEMBL6724437 | 0.69 | EPHX2 (0.46) | EPHX2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |