Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316509 | 0.77 | EPHX2 (0.34) | SIGMAR1LMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6717401 | 0.74 | SIGMAR1 (0.44) | SIGMAR1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8996697 | 0.72 | EPHX2 (0.39) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL6727855 | 0.71 | SIGMAR1 (0.43) | SIGMAR1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL6719600 | 0.70 | SIGMAR1 (0.54) | SIGMAR1LMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6155758 | 0.69 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1CNR2MAPTALOX12 | |
| SCHEMBL6158260 | 0.69 | SIGMAR1 (0.50) | SIGMAR1LMNAALDH1A1CNR2MAPT | |
| SCHEMBL6717118 | 0.68 | SIGMAR1 (0.57) | SIGMAR1ALDH1A1MAPTALOX12HTT | |
| SCHEMBL6724211 | 0.67 | SIGMAR1 (0.58) | SIGMAR1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL6154925 | 0.67 | SIGMAR1 (0.52) | SIGMAR1EPHX2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |