SCHEMBL8997378

SCHEMBL8997378

OCCCCOc1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.45
MAPT P10636 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
PLAU P00749 1/20 0.41
ALDH1A1 P00352 2/20 0.40
LMNA P02545 1/20 0.40
KMT2A Q03164 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 2/20 0.39
TSHR P16473 2/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
MAPK1 P28482 2/20 0.38
TP53 P04637 1/20 0.38
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
S1PR4 O95977 1/20 0.36
PDK2 Q15119 1/20 0.36
CYP3A4 P08684 1/20 0.36
RECQL P46063 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9349699 0.87 MAPT (0.45) KDM4EMAPTTDP1PLAUALDH1A1
SCHEMBL4038561 0.86 PLAU (0.40) KDM4EMAPTPLAUALDH1A1LMNA
SCHEMBL6333482 0.84 PLAU (0.39) KDM4EMAPTTDP1PLAUALDH1A1
SCHEMBL14380211 0.84 MAPT (0.53) KDM4EMAPTTDP1ALDH1A1LMNA
SCHEMBL4054790 0.79 HPGD (0.41) KDM4EMAPTTDP1PLAUALDH1A1
SCHEMBL8408841 0.79 MAPT (0.42) KDM4EMAPTTDP1PLAUALDH1A1
SCHEMBL2089079 0.78 TSHR (0.42) KDM4EMAPTTDP1PLAUALDH1A1
SCHEMBL11567024 0.78 MAPT (0.41) KDM4EMAPTTDP1PLAUKMT2A
SCHEMBL11567229 0.78 MAPT (0.41) KDM4EMAPTTDP1PLAULMNA
SCHEMBL11258112 0.78 S1PR2 (0.49) KDM4EMAPTTDP1AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0544052-B1 Use of a photocurable resin composition for the preparation of a laminated film. DAICEL UCB CO LTD (JP) 1996-09-04 EP disclosed
EP-0544052-A1 Use of a photocurable resin composition for the preparation of a laminated film. DAICEL-UCB CO., LTD. (JP) 1993-06-02 EP disclosed
US-4134814-A Halogenated photopolymerizable adhesives UCB, SOCIETE ANONYME (BE) 1979-01-16 US disclosed
US-4134811-A Halogenated photopolymerizable compositions UCB, SOCIETE ANONYME (BE) 1979-01-16 US disclosed