Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27685426 | 0.87 | LMNA (0.38) | LMNA | |
| Urea SCHEMBL5011099 | 0.85 | LMNA (0.36) | LMNA | |
| Methylamine SCHEMBL110166 | 0.84 | LMNA (0.41) | LMNA | |
| Hydrazine SCHEMBL28825171 | 0.84 | LMNA (0.41) | LMNA | |
| Methyl Alcohol SCHEMBL9617023 | 0.84 | LMNA (0.41) | LMNA | |
| SCHEMBL8130395 | 0.84 | LMNA (0.44) | LMNA | |
| SCHEMBL35169 | 0.84 | LMNA (0.44) | LMNA | |
| Acetamide SCHEMBL15514561 | 0.83 | LMNA (0.38) | LMNA | |
| SCHEMBL27704377 | 0.83 | LMNA (0.35) | LMNA | |
| SCHEMBL27605444 | 0.83 | LMNA (0.35) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545774-B1 | Silica supports modified by grafting polyalkylguanidinium groups, process for their preparation and their use as catalysts | POUDRES & EXPLOSIFS STE NALE (FR) | 1996-08-14 | — | — | EP | disclosed |
| EP-0545774-A1 | Silica supports modified by grafting polyalkylguanidinium groups, process for their preparation and their use as catalysts | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1993-06-09 | — | — | EP | disclosed |