Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8984934 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2HCAR2KEAP1NFE2L2POLB | |
| SCHEMBL10560406 | 0.92 | NPSR1 (0.46) | SMN1; SMN2POLBNPSR1EPHX2EPHX1 | |
| SCHEMBL10560424 | 0.92 | NPSR1 (0.46) | SMN1; SMN2POLBNPSR1EPHX2EPHX1 | |
| SCHEMBL4381636 | 0.90 | NPSR1 (0.49) | SMN1; SMN2POLBNPSR1EPHX2EPHX1 | |
| SCHEMBL4381639 | 0.90 | NPSR1 (0.49) | SMN1; SMN2POLBNPSR1EPHX2EPHX1 | |
| SCHEMBL2082055 | 0.81 | NPSR1 (0.44) | HCAR2NPSR1TSHREPHX1MAPT | |
| SCHEMBL2082056 | 0.81 | NPSR1 (0.44) | HCAR2NPSR1TSHREPHX1MAPT | |
| SCHEMBL1242806 | 0.74 | LMNA (0.43) | NPSR1TSHRMMP2EPHX1MAPT | |
| SCHEMBL1242807 | 0.74 | LMNA (0.43) | NPSR1TSHRMMP2EPHX1MAPT | |
| SCHEMBL10561685 | 0.73 | LMNA (0.45) | NPSR1MMP2EPHX1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6179654-A | — | — | None | — | — | JP | disclosed |
| US-5559139-A | ANTIISCHEMIC AGENTS, MICROCIRCULATION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-09-24 | — | — | US | disclosed |
| JP-H06179654-A | 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTER | BAYER AG | 1994-06-28 | — | — | JP | disclosed |